In this work,a novel surface plasmon resonance(SPR)-based photonic crystal fiber(PCF)biosensor is investigated for real-time detection of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).By the interaction of the ligands on the sensing surface with the virus,the analyte's re-fractive index(RI)ranges from 1.334-1.355.Three structures with different basic resonant materials are analyzed and evaluated based on the finite element method(FEM),including gold,silver,and silver with a titanium dioxide protective layer.The sensor's wavelength works in visible,and the amplitude sensitivity(AS),wavelength sensitivity(WS),resolution,limit of detection(LoD)and figure of merit(FOM)reach up to-1170.89 RIU-1,4 000 nm/RIU,2.5 × 10-5 RIU,6.3× 10-9 RIU2/nm and 911.50 RIU-1,respectively.Results demonstrate that the proposed sensor has excellent potential in the de-tection of SARS-CoV-2,with excellent AS and LoD,which can be used for early and rapid detection.
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