Preparation and Properties of Poly(p-dioxanone)/Polyvinyl Alcohol Composite Hydrogels
Biodegradable poly(p-dioxanone)(PPDO)was introduced into the network of polyvinyl alcohol(PVA)hydrogel,and the PPDO/PVA composite hydrogel with controllable biodegradation period was prepared by freeze-thaw method.By adjusting the ratio of low molecular weight PPDO to high molecular weight PVA,a polymer network interpenetrating structure was formed between PPDO flexible molecular chain and PVA molecular chain,so as to improve the mechanical properties and biodegradability of the hydrogel.The structure and properties of the hydrogel were characterized by infrared FT-IR,SEM and universal testing machine.The swelling property,water loss property,degradation property and antibacterial property of the hydrogel were tested.The results show that the PPDO/PVA composite hydrogel presents a three-dimensional network structure with uniform pores,and its tensile strength and compressive strength are 1～3 times higher than those of pure PVA hydrogel.When it was degraded in PBS buffer solution at 37℃,the degradation rate is obviously improved,and it could be degraded by 45%in 35 d,and it maintains excellent mechanical strength in the period of wound healing.The plate bacterial culture experiment proves that the composite hydrogel has antibacterial properties.The PPDO/PVA composite hydrogel has a wide application prospect in the field of wound dressing.
NETL
NSTL
万方数据
