聚对二氧环己酮/聚乙烯醇复合水凝胶的制备及性能
Preparation and Properties of Poly(p-dioxanone)/Polyvinyl Alcohol Composite Hydrogels
郭守城 1邢瑞权 1杜学超 1范雨薪 1周善立 1庞晓旭 1于晓亮 1樊志 1郭敏杰1
作者信息
- 1. 天津科技大学化工与材料学院;天津科技大学生物源纤维制造技术国家重点实验室,天津 300457
- 折叠
摘要
在聚乙烯醇(PVA)水凝胶的网络中引入完全生物降解的聚对二氧环己酮(PPDO),采用冻融法制备出生物降解周期可控的PPDO/PVA复合水凝胶.通过调整低分子量PPDO与高分子量PVA之间的比例,使PPDO柔性分子链与PVA分子链之间形成聚合物网络互穿结构,实现改善水凝胶力学性能和生物降解性能的目的.采用红外光谱、扫描电镜和万能试验机对水凝胶进行了结构表征和性能测试;并通过溶胀性能及失水性能测试、降解性能测试和抑菌性测试对水凝胶进行了研究.结果表明,PPDO/PVA复合水凝胶呈现出孔隙均匀的三维网络结构,拉伸强度和压缩强度与纯PVA水凝胶相比提高了1～3倍;在37℃的PBS缓冲溶液中降解,降解速率明显提升,35 d可以降解45%,且在伤口愈合的周期内保持优异的力学强度.平板细菌培养实验证明了复合水凝胶具有抑菌的特性.PPDO/PVA复合水凝胶在伤口敷料领域具有广泛的应用前景.
Abstract
Biodegradable poly(p-dioxanone)(PPDO)was introduced into the network of polyvinyl alcohol(PVA)hydrogel,and the PPDO/PVA composite hydrogel with controllable biodegradation period was prepared by freeze-thaw method.By adjusting the ratio of low molecular weight PPDO to high molecular weight PVA,a polymer network interpenetrating structure was formed between PPDO flexible molecular chain and PVA molecular chain,so as to improve the mechanical properties and biodegradability of the hydrogel.The structure and properties of the hydrogel were characterized by infrared FT-IR,SEM and universal testing machine.The swelling property,water loss property,degradation property and antibacterial property of the hydrogel were tested.The results show that the PPDO/PVA composite hydrogel presents a three-dimensional network structure with uniform pores,and its tensile strength and compressive strength are 1～3 times higher than those of pure PVA hydrogel.When it was degraded in PBS buffer solution at 37℃,the degradation rate is obviously improved,and it could be degraded by 45%in 35 d,and it maintains excellent mechanical strength in the period of wound healing.The plate bacterial culture experiment proves that the composite hydrogel has antibacterial properties.The PPDO/PVA composite hydrogel has a wide application prospect in the field of wound dressing.
关键词
聚对二氧环己酮/水凝胶/冻融法/伤口敷料Key words
poly(p-dioxanone)/hydrogel/freeze-thaw method/wound dressing引用本文复制引用
基金项目
中央引导地方科技发展专项(21ZYQCSY00050)
出版年
2024
NETL
NSTL
万方数据