Bacterial infections can cause wound inflammation,make wound healing difficult,and there is an urgent need to develop intelligent hydrogel dressings that are highly effective in their antibacterial,anti-inflammatory properties,and can promote re-epithelialization and angiogenesis.The pH sensitive antibacterial hydrogel IA/AM/TAAC@PHMG was prepared by one pot method using itaconic acid(IA),acrylamide(AM)and allyl trimethylammonium chloride(TAAC)as raw materials for covalent cross-linking,loaded with the antibacterial drug polyhexamethylene guanidine hydrochloride(PHMG).The mechanical properties,swelling properties,drug release properties,antimicrobial properties,biocompatibility,and pro-infectious wound healing properties were tested.The results show that TAAC increases the flexibility of hydrogels and the breaking elongation of hydrogels is increased by 88%;the hydrogels are pH-responsive,can respond positively to wound,pH,control and prolong the release of PHMG,the release rate of PHMG under alkaline conditions(pH 8.2)(60.65%)is better than 14.97% under acidic conditions(pH 3.2);the antibacterial rate of IA/AM/TAAC@PHMG against E.coli and S.aureus is over 99.98%;the cell relative survival rate in the hydrogel group(320 μg/mL)is above 75.08%,the cell hemolysis rate is below 4%,the antibacterial hydrogel has a good biocompatibility;histological analysis prove that the IA/AM/TAAC@PHMG loaded hydrogel can create an environment conducive to granulation growth and excellent antibacterial properties,to reduce the inflammatory factors,promote both collagen and skin regeneration,accelerate wound healing.
NETL
NSTL
万方数据
