Biomimetic Natural Polymer Hydrogels for Medical Material Applications
Natural polymer hydrogels with a highly hydrated three-dimensional polymer network structure show unique adhesion properties that are highly efficient in controlling bleeding and reducing secondary infections.Moreover,they are biocompatible and biodegradable,making them an ideal material for medical adhesives.In recent years,in view of the increasingly stringent requirements for underwater wet viscosity and biodegradability in the research and development of medical adhesives,new adhesion materials with water resistance,biological safety and shape controllability have become a hot spot and difficult point in research.The adhesion of natural organisms to various substrates is mainly dependent on their composition or structure,and biomimetic use of natural polymeric hydrogel materials,which can combine excellent tissue adhesion,haemostasis and bacteriostatic properties and shape controllability,is an effective strategy to address these issues.This paper outlines the adhesion mechanisms of two types of bionic natural polymeric hydrogel materials,discusses the compositional properties of mussel,barnacle and oyster and the structural characteristics of saltwater fish and extracellular matrix as well as the adhesion mechanism in a targeted manner,and introduces the research progress of the corresponding bionic natural polymeric hydrogel materials in tissue healing,wound hemostasis and drug delivery.Finally,the future directions of bionic natural polymer hydrogels are presented and the suggestions are provided.
Medical adhesiveBionic designHydrogelNatural polymer
NETL
NSTL
万方数据
维普
