Studies on Natural Polysaccharides Used as Nucleic Acid Carriers
Gene therapy,a revolutionary treatment method,has opened up a new way of thinking in the treatment of cancer.The most critical problem of gene therapy is the realization of nucleic acid drugs targeting tumor tissues and precise treatment.Direct delivery of nucleic acid drugs has the problems of nuclease degradation and metabolism,negative charge rejection on cell membrane and poor stability,so nucleic acid drugs need the assistance of the carrier.Successful carrier delivery can not only enrich nucleic acid drugs in tumor areas,but also play the role of drug controlled release.Natural polysaccharide is non-toxic,biocompatibe,elasy to modify,and has immunomodulatory,anti-tumor,anti-inflammatory and other biological activities.This review summarizes the structural characteristics of the five most representative polysaccharides and their applications in nucleic acid drug delivery,and then describes the common nanoscale carrier forms of polysaccharides,which lays a foundation for the construction of a new nucleic acid delivery system based on natural polysaccharides and its application in immunoantitumor therapy.
Gene therapyNucleic acid drugsNatural polysaccharidesDurg delivery system
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