刺激响应性介孔二氧化硅药物递送系统的研究进展
Research Progress in Stimulus-responsive Mesoporous Silica Drug Delivery Systems
欧阳溢凡 1黄梦婷 2陈雅娟 2陈艳 1王基伟 1艾克拜尔·热合曼1
作者信息
- 1. 宁德师范学院,闽东畲医药福建省高校工程研究中心,宁德 352100
- 2. 宁德师范学院,闽东畲医药福建省高校工程研究中心,宁德 352100;福州大学化学学院,福州 350100
- 折叠
摘要
介孔二氧化硅纳米粒子(mesoporous silica nanoparticles,MSNs)作为新型的纳米材料,由于其独特的理化性能已成为最有前途的药物递送系统(drug delivery systems,DDSs)之一.而使用聚合物对MSNs表面进行功能化,可实现智能和可控的药物传递特性,即在pH、温度、光、酶、超声或氧化还原等特定环境刺激下释放,从而提高其治疗效率、减少副作用、延长药物作用时间等,在药物控释和肿瘤等疾病治疗方面具有重要的研究意义和良好的应用前景.本文综述了近年来各种响应性MSNs在药物靶向输送和肿瘤等疾病治疗应用的研究进展,以期为响应性MSNs在生物医学应用,特别是DDSs应用研究方面提供一定的参考.
Abstract
As a new type of nanomaterial,mesoporous silica nanoparticles(MSNs)have become one of the most promising drug delivery systems(DDSs)due to their unique physicochemical properties.The use of responsive polymer brushes to functionalize the surface of MSNs can achieve intelligent and controllable drug delivery,release under specific environmental stimuli such as pH,temperature,light,enzyme,ultrasound or redox,thereby improving its therapeutic efficiency,reducing side effects,extending drug action time.It has important research significance and good application prospect in drug controlled release and tumor treatment.In this paper,the research progress of various responsive MSNs in targeted drug delivery and tumor treatment in recent years is reviewed,in order to provide some reference for the application of responsive MSNs in biomedicine,especially the application of drug carriers.
关键词
介孔二氧化硅纳米粒子/药物递送系统/刺激响应性/聚合物/靶向释放Key words
Mesoporous silica nanoparticles(MSNs)/Drug delivery systems/Stimulus responsiveness/Polymer/Targeted release引用本文复制引用
基金项目
福建省自然科学基金(2023J05207)
宁德师范学院创新团队项目(2022T03)
宁德师范学院创新团队项目(2023T05)
出版年
2024
NETL
NSTL
万方数据