Research Progress in Stimulus-responsive Mesoporous Silica Drug Delivery Systems
As a new type of nanomaterial,mesoporous silica nanoparticles(MSNs)have become one of the most promising drug delivery systems(DDSs)due to their unique physicochemical properties.The use of responsive polymer brushes to functionalize the surface of MSNs can achieve intelligent and controllable drug delivery,release under specific environmental stimuli such as pH,temperature,light,enzyme,ultrasound or redox,thereby improving its therapeutic efficiency,reducing side effects,extending drug action time.It has important research significance and good application prospect in drug controlled release and tumor treatment.In this paper,the research progress of various responsive MSNs in targeted drug delivery and tumor treatment in recent years is reviewed,in order to provide some reference for the application of responsive MSNs in biomedicine,especially the application of drug carriers.
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