Stimulus-responsive Polymeric Nanocarriers for Platinum Drug Delivery
Platinum(Pt)drugs are the most common chemotherapeutic agents in the clinic due to their unique anticancer mechanism,which endows them with high efficiency and broad-spectrum resistance to tumors.However,the toxicity and side effects induced by Pt drugs,also,the drug resistance limits the therapeutic effects of Pt drugs.With the development of nanotechnology,the use of nanocarriers to realize the targeted delivery of Pt drugs has become a hot research topic in recent years.Among the various kinds of nanocarriers,the development of stimuli-responsive polymeric nanocarriers has become a trend in the construction of Pt drug delivery systems at this stage.On the one hand,polymer-based nano-delivery system is capable of taking advantage of polymer segments to enhance loading capacity and achieve the conjugation of different drugs.On the other hand,it is capable of utilizing the tumor microenvironment to achieve the precise delivery and accumulation and penetration of Pt drugs through stimulation response.According to the classification of stimuli-responsive sources,this review overviews the recent progress of different stimuli-responsive polymeric nanocarriers to deliver Pt drugs efficiently,following the introduction of platinum drugs.The design strategy and the controlled-release mechanism of polymeric nanocarriers are analyzed with emphasis.This review aims to provide the research and development(R&D)idea and theoretical support for a clinically applicable polymer-based nano-delivery system for Pt drugs.
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