Study on Preparation and Specific Separation Properties of Boronate Affinity-based Surface Molecularly Imprinted Microspheres with Naringin as Template
Boric acid functionalized polymer microspheres were prepared via suspension polymerization by using methacrylate(MMA)and 4-vinylphenylboronic acid(VPBA)as functional monomers,and ethyleneglycol dimethacrylate(EDMA)as crosslinkers,respectively.Naringin template was covalently anchored onto the surface of the microspheres by boronate affinity,and then a thin coating layer of dopamine and polyethyleneimine was formed onto the microspheres surface via oxidative self-copolymerization.After removal of the template with an acidic solution,the naringin surface molecularly imprinted microspheres(SMIMs)based on boronate affinity were obtained.The resulting materials were characterized by scanning electron microscopy,laser confocal microscopy,water contact angle experiment,nitrogen adsorption/desorption and infrared spectroscopy.The results show that the hydrophilic imprinted film has been successfully formed on the surface of boric acid functionalized polymer microspheres(BPMs).The adsorption experiments indicate that the SMIMs possess high adsorption capacity,excellent specific selectivity and fast adsorption kinetic rate toward template under water phase conditions.In addition,the extraction experiments reveal that the SMIMs as the adsorbed materials of solid phase extraction(SPE)can effectively separate naringin from Exocarpium Citri Grandis extract,and the total recovery of elution solution can reach 50.52％.
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