Fabrication of D-tyrosine and Polymyxin B Modified Polymer Coatings and Their Functions in Resisting Bacterial Biofilm Formation
Poly(vinyl chloride)(PVC)medical catheters are prone to form bacterial biofilms and result in bacterial infections during application,which pose formidable threat to public health.As the antibiotic molecules are difficult to penetrate into the biofilms to kill bacteria,there is an urgent demand in developing polymer coatings to resist the formation of bacterial biofilms.Herein,the functional molecules of D-tyrosine,which triggers the disassembly of biofilms,polymyxin B,which is able to kill bacteria,and aldehyde-modified dextran,which has good biocompatibility,are modified onto the surface of PVC,and their functions in resisting the formation of bacterial biofilms are studied.The results show that the polymer coatings modified with D-tyrosine can resist the formation of bacterial biofilms on the substrate of PVC and reduce the tissue inflammation caused by bacterial infections.This research provides a new strategy for the manufacturing of biofilm-resisting PVC catheters for medical applications.
NETL
NSTL
万方数据
维普
