Studies on the Microfluidic Preparation and Properties of Monodisperse,Highly Elastic Drug-loading Hydrogel Microspheres Toward Embolization Therapy
The aim of this paper is to prepare drug-loaded,highly elastic hydrogel microspheres with monodisperse size distribution and adjustable diameters using a single-emulsion capillary microfluidic device for potential embolization therapy.Aqueous solution of acrylamide(AM)and potassium 3-sulfopropyl methacrylate(SPMA)(monomers),water soluble photo initiator and homemade macromolecular(MM2)micelle(multifunctional cross-linking agent)was used as the dispersed(inner)phase.Oil soluble photo initiator and surfactants were dissolved in liquid paraffin wax,used as the continuous(outer)phase.Monodisperse inner-phase droplets were obtained in the microfluidic channel,which was then crosslinked and polymerized by ultraviolet irradiation to produce hydrogel microspheres with excellent elasticity.The obtained microsphere could be 3D compressed within a round capillary tube more than 60％without breaking and could immediately recover to its original state.The microsphere could quickly load the cationic anticancer drug doxorubicin hydrochloride with high capacity,and the encapsulation efficiency exceeded 97％within 20 min.The equilibrium drug loading capacity was about 648 mg/g(dry spheres)and 95 mg/g(wet spheres).In addition,the drug release behaviors of drug loaded microspheres with different particle sizes in different media were also studied and discussed.These results provide some new experimental and theoretical supports for the preparation of monodisperse,highly elastic and high drug loading hydrogel microspheres,especially for their potential application of embolic microspheres.
万方数据
维普
