摘要
细胞膜是细胞的外层包裹结构,保护细胞内部免受外界干扰.通过对细胞膜进行修饰,引入特定的分子或结构,可以实现对细胞命运和功能的调控,从而赋予细胞特殊的功能.近年来,利用高分子材料在细胞膜上发生自组装的策略用于功能化修饰细胞膜表面已被广泛研究.本文综述了利用高分子、多肽及DNA纳米材料对细胞膜进行修饰的策略,总结了其带来的包括受体寡聚化、细胞膜通透性改变以及调节细胞间通讯的生物效应以及细胞膜表面功能化的生物应用.
Abstract
The cell membrane,the outer protective structure of a cell,serves to shield its internal components from external disruptions.By manipulating the cell membrane and incorporating specific molecules or structures,one can exert control over the fate and functionality of cells,thereby imbuing them with specialized functions.In recent years,the strategy of using biomacromolecules to self-assemble on cell membranes has been widely studied for functionalizing the surface of cell membranes.This paper reviews that the self-assembly of different biomacromolecules on the cell membrane surface can change the biological effects of cells and produce positive effects in tumor immunotherapy.It is elaborated that when biomacromolecular materials are self-assembled on the cell membrane,it can cause biological effects of cells,such as oligomerization of cell membrane receptor proteins to activate immune cells,changing cell membrane permeability to promote endocytosis,etc.At the same time,its application in tumor treatment is briefly introduced,and the future development of self-assembly technology modified cell membrane surface is prospected.
基金项目
国家重点研发计划项目(2020YFA0210800)
NETL
NSTL
万方数据