聚硫辛酸基多功能水凝胶的构建及在感染皮肤伤口修复中的应用
Construction of Poly(lipoic acid)-based Functional Hydrogels for Infected Skin Wound Healing
杜佳强 1张彦峰 1成一龙1
作者信息
- 1. 西安交通大学化学学院 西安 710049
- 折叠
摘要
以α-硫辛酸(LA)为单体,借助其强还原性与浓度和温度诱导开环聚合,一步法制备了负载纳米银(AgNPs)的氢键交联高分子水凝胶,并对其可注射性、自修复性、粘接能力、光热效应、抗氧化能力以及生物相容性进行了详细地研究.在细菌感染的大鼠全层皮肤损伤模型中,该高分子水凝胶敷料可以通过光热效应杀死细菌,同时有效降低伤口处的活性氧(ROS)水平,进而调控组织损伤的炎症反应,促进感染伤口的加速愈合.
Abstract
Poly(lipoic acid)-based functional hydrogels incorporated with silver nanoparticles(AgNPs)are developed for bacteria-infected skin wound healing in this work.Owing to the reducibility of α-lipoic acid(LA),AgNO3 can be converted into AgNPs in the local hydrogel network(PLAS@AgNPs hydrogels),which are synthesized by concentration-and thermo-induced ring-opening polymerization of LA in the presence of NaHCO3.Benefiting from the dynamic nature of hydrogen bonds formed by-COOH groups,PLAS@AgNPs hydrogels feature facile injectability and self-healing ability,and exhibit stable adhesion behavior with porcine skin tissues(36 kPa).The resulting hydrogels show promising photothermal efficiency due to the in situ formation of AgNPs,and the temperature of the hydrogels can be elevated by 38 ℃ with the irradiation of near-infrared(NIR)light for 10 min,which can effectively inhibit the proliferation of escherichia coli and staphylococcus aureus.Moreover,the PLAS@AgNPs hydrogels can also clear the intracellular reactive oxygen species(ROS)inherited from the antioxidant nature of LA.In a rat full-thickness skin injury model with bacterial infection,the PLAS@AgNPs hydrogel dressing can accelerate the skin wound healing with the assistance of NIR light irradiation through the synergistic effect of anti-bacteria and ROS scavenging.
关键词
水凝胶/氢键/硫辛酸/光热效应/皮肤损伤修复Key words
Hydrogel/Hydrogen bond/α-Lipoic acid/Photothermal effect/Skin wound healing引用本文复制引用
基金项目
国家自然科学基金(52322309)
国家重点研发计划(2023YFB3810400)
西安交通大学青年拔尖人才支持计划()
出版年
2024
NETL
NSTL
万方数据