Flexible Fiber Glucose Sensor Based on Direct Electron Transfer
Real-time monitoring of glucose concentration in vivo holds significant importance for disease diagnosis and treatment.The enzyme-based electrochemical glucose sensor has garnered considerable attention in the realm of real-time glucose monitoring due to its outstanding selectivity and sensitivity.Despite the development of first and second generation electrochemical glucose sensors,they encounter numerous challenges derived from their sensing principles,including interference from oxygen concentration,instability of electronic mediators,and leaching toxicity.The third generation of glucose sensor based on direct electron transfer between enzyme and electrode is anticipated to address these challenges.Here,we report an all-polymer-based flexible fiber glucose sensor(FGS)based on direct electron transfer,leveraging poly(3,4-vinyldioxythiophene):polystyrene sulfonate(PEDOT:PSS)and glucose dehydrogenase(GDH)as its constituents.The FGS exhibits commendable linearity(R2=0.9968)within the range of 10-500 μmol/L and demonstrates a sensitivity of 62.53 μA/(mmol·L-1·cm2).The FGS is seamlessly integrated into fabric,enabling continuous real-time monitoring of glucose levels in human sweat during exercise.This work presents a novel approach for developing the third-generation glucose sensors to cater to the requirements of wearable technology.
Flexible fiberGlucose sensorDirect electron transferSweat monitoringPoly(34-vinyldioxythiophene):polystyrene sulfonate
万方数据
维普
