Based on the synergistic non-covalent interaction of tadpole-like single-chain particles with multiple sites on the wafer surface,a PEG brush grafting strategy has been developed that combines ease of handling and excellent"biofouling"properties.Specifically,the block copolymer poly(ethylene glycol)-b-poly(4-vinylpyridine)(PEG-b-P4VP)was synthesized by atom transfer radical polymerization(ATRP).The P4VP block was then intra-chain cross-linked using the"electrostatic-mediated"strategy,and the P4VP"head"was completely quaternized by further addition of excess ethyl iodide,yielding tadpole-like single-chain particles with completely quaternized"heads"(TSCP-Q).By simple solution immersion grafting method,the completely cross-linked and collapsed"head"significantly reduces its adsorption area on the silicon wafer through multi-site non-covalent synergistic interaction,while the extended PEG"tail"ensures grafting uniformity of TSCP-Q brushes on the surface through volume repulsion effect.As a result,the obtained TSCP-Q brushes achieve stable and uniform grafting on the silicon wafer,with PEG"tail"overlying the P4VP"head"anchoring layer and effectively masking the charge of the anchoring layer.The TSCP-Q brushes were shown to have excellent anti-bovine serum albumin(BSA)adsorption(4.8 ng/cm2)and could effectively inhibit the colonization of Staphylococcus aureus(S.aureus)(killing efficacy upto 81％).
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