The Value of a Combined Intratumoral and Peritumoral Radiomics Model Based on Contrast-enhanced CT in Distinguishing Papillary Thyroid Carci-noma from Nodular Goiter
Objective:To investigate the value of a combined intratumoral and peritumoral three-dimensional radiomics model based on contrast-enhanced CT in preoperatively discriminating between papillary thyroid carcinoma(PTC)and nodular goiter(NG).Methods:A retrospective analysis was conducted on 157 patients with thyroid nodules confirmed by surgical pathology,including 80 cases of PTC and 77 cases of NG,who were randomly divided into a training set(N=112)and a validation set(N=45)at a ratio of 7:3.Three-dimensional radiomics features were extracted from the intratumoral and peritumoral 2 mm regions on contrast-enhanced CT arterial phase images using Pyradiomics software.The optimal radiomics features were selected through Z-score standardization,statistical tests,Pearson correlation analysis,and the least absolute shrinkage and selection operator(LASSO)algorithm.Random forest(RF)algorithms were used to establish models for intratumoral,peritumoral,and combined intratumoral and peritumoral regions to discriminate between PTC and NG.The diagnostic performance of the models was evaluated using ROC curves and decision curves.Results:A total of 4,8,and 11 most discriminative radiomics features were selected from intratumoral,peritumoral,and combined intratumoral and peritumoral regions,respectively,for model construction.The model combining intratumoral and peritumoral regions showed the best predictive performance,with AUCs of 0.965 and 0.934 for the training and validation sets,respectively.The decision curves indicated superior clinical utility in the 0.1％to 1.0％range of threshold probability.Conclusion:The CT-enhanced intratumoral and peritumoral radiomics model can effectively discriminate between papillary thyroid carcinoma and nodular goiter.
万方数据
维普
