Exploration the Diagnostic Value of Contrast-enhanced Ultrasound Combined with Serum SCC and CYFRA 21-1 in Cervical Lymph Node Metastasis of Esophageal Squamous Cell Carcinoma
Objective:To explore the application value of contrast-enhanced ultrasound combined with serum squamous cell carcinoma associated antigen(SCC)and cytokeratin 19 fragment 21-1(CYFRA 21-1)in the diagnosis of cervical lymph node metastasis of esophageal squamous cell carcinoma.Methods:164 esophageal squamous cell carcinoma patients admitted from April 2020 to August 2023 were selected,and they were divided into a metastatic group(n=58)and a non metastatic group(n=106)based on postoperative pathological examination.All patients were tested for contrast-enhanced ultrasound and serum SCC and CYFRA 21-1 levels before surgery.The contrast-enhanced ultrasound parameters[peak intensity(PI),time to peak(TTP),mean transit time(MTT)]andserum marker levels were compared in two groups,and the diagnostic value was analyzed through ROC curve.Results:The PI,MTT and serum SCC,CYFRA 21-1 levels in the metastatic group were significantly higher than those in the non metastatic group(P＜0.05),while the TTP was significantly lower than that in the non metastatic group(P＜0.05).The sensitivity,specificity and AUC of the combined diagnosis of three contrast-enhanced ultrasound parameters were 79.31％,81.13％and 0.821 respectively,and the sensitivity increased to 96.55％and the AUC increased to 0.913 after combining with serum markers(P＜0.05).Conclusion:The contrast-enhanced ultrasound combined with serum SCC and CYFRA 21-1 levels can significantly improve the diagnostic efficiency of cervical lymph node metastasis in esophageal squamous cell carcinoma,and they provide a basis for the development of individualized clinical treatment plans.
contrast-enhanced ultrasoundsquamous cell carcinoma associated antigencytokeratin 19 fragment 21-1esophageal squamous cell carcinomacervical lymph node metastasisdiagnostic value
万方数据
维普
