Obesity is an important manifestation of the imbalance of energy regulation,and its complications can cause ir-reparable damage to the body.Finding the pathogenesis of obesity at the molecular level can help fundamentally avoid these irreversible complications.Extended synaptotagmins(E-Syts)are proteins related to the formation of endoplasmic reticulum(ER)and plasma membrane(PM).Because of the short discovery time,there is huge room for exploration.In terms of the role of the established structure of E-Syts at the molecular level,it has a non-negligible link with the pathogenesis of obesi-ty.Starting with the structure of hypothalamus,this paper reviews the literature evidence of this connection,hoping to find a new research angle for reducing the incidence of obesity.
关键词
能量平衡/内质网-细胞膜连接/内质网应激/下丘脑/延伸突触结合蛋白
Key words
Energy balance/Endoplasmic reticulum-plasma membrane junction/Endoplasmic reticulum stress/Hypothalamus/Extended synaptotagmins
维普
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