摘要
目的 了解肥胖2型糖尿病(type 2 diabetes mellitus,T2DM)患者白介素-6(IL-6)、趋化素(chemerin)、总胆固醇(TC)与高密度脂蛋白胆固醇(HDL-C)比值、三酰甘油(TG)与HDL-C比值、低密度脂蛋白胆固醇(LDL-C)与HDL-C比值与胰岛素抵抗的相关性,为T2DM防控提供科学依据.方法 选取2021年1月至2023年12月上海交通大学医学院附属松江医院收治的355例肥胖T2DM患者,均进行IL-6、chemerin和脂质检测,并通过稳态模型评估胰岛素抵抗指数(HOMA-IR).结果 355例肥胖T2DM患者中,发生胰岛素抵抗者280例,即胰岛素抵抗发生率为 78.87％.胰岛素抵抗组 BMI、IL-6、chemerin、TC/HDL-C、LDL-C/HDL-C、TG/HDL-C 均大于无胰岛素抵抗组(P＜0.05).根据胰岛素抵抗分为4个亚组,各亚组BMI、IL-6、chemerin、TG/HDL-C比较差异均显著(P＜0.05).肥胖 T2DM 患者 IL-6、chemerin、TG/HDL-C 与 HOMA-IR 呈成正相关(P＜0.05),TC/HDL-C、LDL-C/HDL-C 与 HOMA-IR 无明显相关性(P＞0.05).BMI、IL-6、chemerin、TG/HDL-C 均是肥胖 T2DM 患者胰岛素抵抗的影响因素(P＜0.05).结论 肥胖T2DM患者IL-6、chemerin、TG/HDL-C与胰岛素抵抗存在相关性,可能是胰岛素抵抗发生的影响因素.
Abstract
Objective To investigate the correlation between insulin resistance and interleukin-6(IL-6),chemerin,total cholesterol(TC)/high density lipoprotein cholesterol(HDL-C)ratio,triglyceride(TG)/HDL-C ratio,low density lipoprotein cholesterol(LDL-C)/HDL-C ratio and insulin resistance in obese patients with type 2 diabetes mellitus(T2DM),and to provide scientific basis for T2DM prevention and control.Methods A total of 355 obese T2DM patients in Songjiang Hospital Affiliated to Shanghai Jiaotong University School of Medicine were selected from January 2021 to December 2023.IL-6,chemerin and lipids were detected,and the assessment of insulin resistance was conducted through the homeostasis model assessment of insulin resistance(HOMA-IR).Results Among the 355 obese T2DM patients,there were 280 cases of insulin resistance,with the incidence rate of 78.87％.The BMI,IL-6,chemerin,TC/HDL-C,LDL-C/HDL-C,and TG/HDL-C in the insulin resistance group were higher than those in the non-insulin resistance group(P＜0.05).The above insulin resistant patients were divided into 4 subgroups by means of insulin resistance,and there were significant differences in BMI,IL-6,chemerin,and TG/HDL-C among the subgroups(P＜0.05).IL-6,chemerin,and TG/HDL-C were positively correlated with HOMA-IR in obese T2DM patients(P＜0.05),while TC/HDL-C and LDL-C/HDL-C had no significant correlation with HOMA-IR(P＞0.05).BMI,IL-6,chemerin,and TG/HDL-C were all influencing factors of insulin resistance in obese T2DM patients(P＜0.05).Conclusion IL-6,chemerin and TG/HDL-C are correlated with insulin resistance in obese patients with T2DM and are influencing factors for the occurrence of insulin resistance.
维普
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