Correlation between IL-6,chemerin,lipid ratio and insulin resistance in obese patients with type 2 diabetes mellitus
Objective To investigate the correlation between insulin resistance and interleukin-6(IL-6),chemerin,total cholesterol(TC)/high density lipoprotein cholesterol(HDL-C)ratio,triglyceride(TG)/HDL-C ratio,low density lipoprotein cholesterol(LDL-C)/HDL-C ratio and insulin resistance in obese patients with type 2 diabetes mellitus(T2DM),and to provide scientific basis for T2DM prevention and control.Methods A total of 355 obese T2DM patients in Songjiang Hospital Affiliated to Shanghai Jiaotong University School of Medicine were selected from January 2021 to December 2023.IL-6,chemerin and lipids were detected,and the assessment of insulin resistance was conducted through the homeostasis model assessment of insulin resistance(HOMA-IR).Results Among the 355 obese T2DM patients,there were 280 cases of insulin resistance,with the incidence rate of 78.87％.The BMI,IL-6,chemerin,TC/HDL-C,LDL-C/HDL-C,and TG/HDL-C in the insulin resistance group were higher than those in the non-insulin resistance group(P＜0.05).The above insulin resistant patients were divided into 4 subgroups by means of insulin resistance,and there were significant differences in BMI,IL-6,chemerin,and TG/HDL-C among the subgroups(P＜0.05).IL-6,chemerin,and TG/HDL-C were positively correlated with HOMA-IR in obese T2DM patients(P＜0.05),while TC/HDL-C and LDL-C/HDL-C had no significant correlation with HOMA-IR(P＞0.05).BMI,IL-6,chemerin,and TG/HDL-C were all influencing factors of insulin resistance in obese T2DM patients(P＜0.05).Conclusion IL-6,chemerin and TG/HDL-C are correlated with insulin resistance in obese patients with T2DM and are influencing factors for the occurrence of insulin resistance.
万方数据
维普
