Epidemic characteristics and factors influencing mortality in HIV/HCV co-infected population in Heilongjiang Region
Objective To investigate the epidemic characteristics and factors influencing mortality in human immunodeficiency virus(HIV)and hepatitis C virus(HCV)-coinfected patients in heilongjiang region.Methods The clinical data of 712 HIV-infected patients attending our hospital from January 2019 to December 2023 were analyzed retrospectively.The HCV infections were detected by ELISA,and epidemic characteristics of HIV/HCV co-infected patients were analyzed.Co-infected patients(n=116)were classified into survival group(n=90)and death group(n=26)according to the follow-up results,and risk factors for the mortality of HIV/HCV co-infected patients were identified.Results The prevalence of HIV/HCV co-infection was 16.29％,and the prevalence was the highest in 30-50 age group,accounting for 25.47％.There was no significant difference in co-infection rates by gender and marital status(P＞0.05).The co-infection rate was the highest among farmers(26.85％)by occupation and among intravenous drug users(61.90％)by route of infection.No statistical difference was found in gender,marital status,and occupational status between survival group and death group(P＞0.05),whereas statistical difference was found in age at diagnosis of HIV infection,route of infection,antiretroviral treatment,percentage of CD4+T lymphocytes,and interval between diagnosis and initiation of treatment between two groups(P＜0.05).Multivariate logistic regression analysis denoted that age at diagnosis of HIV infection(OR=1.827,95％CI:1.263-2.722),route of infection(OR=1.796,95％CI:1.248-2.503),antiretroviral treatment(OR=1.724,95％CI:1.202-2.367),percentage of CD4+T lymphocytes(OR=2.536,95％CI:1.776-3.739),and the time interval between diagnosis and initiation of treatment(OR=1.953,95％CI:1.431-2.952)were all associated with the risk of mortality in co-infected patients(P＜0.05).Conclusion The overall prevalence of HIV/HCV co-infection is 16.29％in heilongjiang region.In order to reduce the mortality rate of superinfection,we should focus on patients who are ≥40 years old,intravenous drug use,no antiviral therapy,low CD4+T lymphocyte levels for the first time,and have a long interval between diagnosis and initiation of treatment.
万方数据
维普
