首页|Recent advances in promising drugs for primary prevention of gastroesophageal variceal bleeding with cirrhotic portal hypertension

Recent advances in promising drugs for primary prevention of gastroesophageal variceal bleeding with cirrhotic portal hypertension

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
  • 维普
Background:Gastroesophageal variceal bleeding is one of the most severe complications of patients with cirrhosis.Although primary prevention drugs,including non-selective β-blockers,have effectively reduced the incidence of bleeding,their efficacy is limited due to side effects and related contraindications.With recent advances in precision medicine,precise drug treatment provides better treatment efficacy.Data sources:Literature search was conducted in PubMed,MEDLINE and Web of Science for relevant articles published up to May 2022.Information on clinical trials was obtained from https://clinicaltrials.gov/and http://www.chictr.org.cn/.Results:The in-depth understanding of the pathogenesis and advances of portal hypertension has enabled the discovery of multiple molecular targets for promising drugs.According to the site of action,these drugs could be classified into four classes:intrahepatic,extrahepatic,both intrahepatic and extrahepatic targets and others.All these classes of drugs offer advantages over traditional treatments in prevention of gastroesophageal variceal bleeding in patients with cirrhotic portal hypertension.Conclusions:This review classified and summarized the promising drugs,which prevent gastroesophageal variceal bleeding by targeting specific markers of pathogenesis of portal hypertension,demonstrating the significance of using the precision medicine strategy to discover and develop promising drugs for the primary prevention of gastroesophageal variceal bleeding in patients with cirrhotic portal hypertension.

Cirrhotic portal hypertensionTarget drugPrimary preventionBleeding

Ji-Yao Sheng、Zi-Fan Meng、Qiao Li、Yong-Sheng Yang

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Department of Hepatobiliary and Pancreatic Surgery,the Second Hospital of Jilin University,Changchun 130041,China

Jilin Engineering Laboratory for Translational Medicine of Hepatobiliary and Pancreatic Diseases,the Second Hospital of Jilin University,Changchun 130041,China

National Natural Science Foundation of ChinaChina Postdoctoral science FoundationYouth Support Project of Jilin Association for Science and TechnologyJilin Provincial Health Special ProjectJilin Health and Healthy Youth Science and Technology Training Plan

819024842020M6708642020282020SCZT0392020Q017

2024

10.1016/j.hbpd.2023.08.003

国际肝胆胰疾病杂志(英文版)
浙江省医学学术交流管理中心,浙江大学医学院附属第一医院,浙江大学出版社有限责任公司

国际肝胆胰疾病杂志(英文版)

影响因子：0.668
ISSN：1499-3872
年,卷(期)：2024.23(1)
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