Ferritinophagy:A new idea for liver diseases regulated by ferroptosis

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国家科技期刊平台
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外文摘要：Background:The discovery of regulatory cell death has led to a breakthrough in the therapeutic field.Various forms of cell death,such as necrosis,apoptosis,pyroptosis,autophagy,and ferroptosis,play an important role in the development of liver diseases.In general,more than one form of cell death path-ways is responsible for the disease state.Therefore,it is particularly important to study the regulation and interaction of various cell death forms in liver diseases.Data sources:We performed a PubMed search up to November 2022 with the following keywords:fer-ritinophagy,ferroptosis,and liver disease.We also used terms such as signal path,inducer,and inhibitor to supplement the query results.Results:This review summarized the basic characteristics of ferritinophagy and ferroptosis and the regu-lation of ferroptosis by ferritinophagy and reviewed the key targets and treatment strategies of ferroptosis in different liver diseases.Conclusions:Ferritinophagy is a potential therapeutic target in ferroptosis-related liver diseases.

作者：

Zi-Bing Qian、Jun-Feng Li、Wan-Yuan Xiong、Xiao-Rong Mao

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作者单位：

The First Clinical Medical College of Lanzhou University,Lanzhou 730000,China

Institute of Infectious Diseases,The First Hospital of Lanzhou University,Lanzhou 730000,China

Department of Infectious Disease,The First Hospital of Lanzhou University,Lanzhou 730000,China

基金：

National Natural Science Foundation of ChinaNatural science Foundation of Gansu ProvinceFund of the First Hospital of Lanzhou UniversityFund of the First Hospital of Lanzhou UniversityGansu Clinical Medical Research Center of Infection & Liver DiseasesNatural Science Foundation of Gansu ProvinceLanzhou Science and Technology Planning Project

项目编号：

8236013220JR5RA364ldyyyn2020-02ldyyyn2020-1421JR7RA39221JR1RA0702023-2-76

出版年：

2024

DOI：

10.1016/j.hbpd.2023.10.005

国际肝胆胰疾病杂志(英文版)

影响因子：0.668

ISSN：1499-3872

年,卷(期)：2024.23(2)

Zi-Bing Qian,Jun-Feng Li,Wan-Yuan Xiong,et al.Ferritinophagy:A new idea for liver diseases regulated by ferroptosis[J].国际肝胆胰疾病杂志(英文版),2024,23(2):160-170.DOI:10.1016/j.hbpd.2023.10.005.

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