首页|Diagnosis and treatment of biliary mucinous cystic neoplasms:A single-center experience

Diagnosis and treatment of biliary mucinous cystic neoplasms:A single-center experience

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
Background:Biliary mucinous cystic neoplasms(BMCNs)are rare hepatobiliary cystic tumors,which can be divided into noninvasive and invasive types.This study aimed to investigate the diagnosis,treatment,and prognosis of BMCNs in a large single center.Methods:We analyzed 49 patients with BMCNs confirmed by postoperative pathology at the First Affili-ated Hospital,Zhejiang University School of Medicine between January 2007 and December 2021.Results:Among the 49 patients,37 were female(75.5％),and the average age was 57.04 years.Common symptoms included abdominal discomfort,jaundice and fever,while 22 patients(44.9％)had no symp-toms.Serum carbohydrate antigen(CA)19-9 and CA125 concentrations were elevated in 34.8％and 19.6％of patients,respectively.Forty-eight patients had tumors in the intrahepatic bile ducts and only one had a tumor in the extrahepatic bile duct.Forty-eight patients with noninvasive intrahepatic BMCNs were further analyzed in terms of pathological features:34(70.8％)had low-grade intraepithelial neoplasms(LGINs),and 14(29.2％)had high-grade intraepithelial neoplasms(HGINs).The potential immunohisto-chemical markers of BMCNs were cytokeratin(CK)19,CK7,estrogen receptor and progesterone receptor.Follow-up data for 37 patients with intrahepatic BMCNs were obtained.The median overall survival(OS)of BMCNs was not reached.The longest survival time was 137 months.The 5-and 10-year OS rates were 100％and 85.4％,respectively.The 5-and 10-year recurrence-free survival(RFS)rates were 93.9％and 80.2％,respectively.Conclusions:BMCNs are rare cystic neoplasms that commonly occur in middle-aged females.BMCNs can only be diagnosed and classified by postoperative pathology,as there are no specific clinical presenta-tions,serological indicators or imaging modalities for preoperative diagnosis.Complete surgical resection is necessary for BMCNs,and the postoperative prognosis is favorable.

Biliary mucinous cystic neoplasmsLow-grade intraepithelial neoplasmsHigh-grade intraepithelial neoplasmsOverall survivalRecurrence-free survival

Jun-Jun Jia、Ya-Fen Cheng、Mei-Bao Feng、Li Liu、Ming-Qi Shuai、Xiao-Dong Shen、Xiao-Feng Tang、Shu-Sen Zheng

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Division of Hepatobiliary and Pancreatic Surgery,Department of Surgery,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China

Department of International Healthcare Center,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China

Department of Pathology,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China

Department of Library,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China

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Zhejiang Natural Science FoundationGeneral Scientific Research Project of Zhejiang Provincial Department of EducationPostgraduate Education Research Project of Zhejiang University

GF21H030024Y20214621920220326

2024

10.1016/j.hbpd.2023.08.011

国际肝胆胰疾病杂志(英文版)
浙江省医学学术交流管理中心,浙江大学医学院附属第一医院,浙江大学出版社有限责任公司

国际肝胆胰疾病杂志(英文版)

影响因子：0.668
ISSN：1499-3872
年,卷(期)：2024.23(5)