首页|Survival benefit of adjuvant treatment for ampullary cancer with lymph nodal involvement:A systematic review and meta-analysis
Survival benefit of adjuvant treatment for ampullary cancer with lymph nodal involvement:A systematic review and meta-analysis
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Survival benefit of adjuvant treatment for ampullary cancer with lymph nodal involvement:A systematic review and meta-analysis
Background:The efficacy of adjuvant treatment(AT)in ampullary cancer(AmC)remains controversial.This systematic review and meta-analysis aimed to evaluate the role of AT for AmC.Data sources:A comprehensive systematic search was performed in PubMed,EMBASE,Cochrane Library,and Web of Science databases.Studies comparing overall survival(OS)and recurrence-free survival(RFS)of patients who underwent AT or not following AmC resection were included.Results:A total of 3971 patients in 21 studies were analyzed.Overall pooled data showed no significant difference in effect on the OS by AT[hazard ratio(HR)=0.998,95％confidence interval(CI):0.768-1.297].No significant difference in recurrence between the AT and non-AT(nAT)groups was noted(HR=1.158,95％CI:0.764-1.755).In subgroup analysis,patients who received AT showed favorable outcomes in the OS compared with those who received nAT in nodal-positive AmC(HR=0.627,95％CI:0.451-0.870).Neither AT consisted of adjuvant chemotherapy with radiotherapy(HR=0.804,95％Cl:0.563-1.149)nor AT with adjuvant chemotherapy(HR=0.883,95％CI:0.642-1.214)showed any significant effect on the OS.Conclusions:The effect of AT in AmC on survival and recurrence did not show a significant benefit.Furthermore,effectiveness according to AT strategies did not show enhancement in survival.AT had an advantage in survival compared with nAT strategy in nodal-positive AmC.In cases of AmC with positive lymph nodal involvement,AT may be warranted regardless of detailed strategies.
Ampulla of VaterAdjuvant chemotherapyAdjuvant chemoradiotherapyMeta-analysis
Min Kyu Kim、Jin Ho Choi、In Rae Cho、Sang Hyub Lee、Ji Kon Ryu、Yong-Tae Kim、Woo Hyun Paik
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Department of Gastroenterology,Asan Medical Center,University of Ulsan College of Medicine,Seoul,Korea
Department of Internal Medicine,Liver Research Institute,Seoul National University Hospital,Seoul National University College of Medicine,Seoul,Korea
Ampulla of Vater Adjuvant chemotherapy Adjuvant chemoradiotherapy Meta-analysis
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