Molecular structure and application of covalent organic frameworks(COFs)in tumor therapy

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外文标题：Molecular structure and application of covalent organic frameworks(COFs)in tumor therapy

外文摘要：The field of nanomedicine has emerged as a vital component in cancer treatment modalities over the past decades.Covalent organic frameworks(COFs)at the nanoscale have become a novel and promising category of biomaterials in the field of nanomedicine.Their distinctive properties,such as low density,exceptional porosity,crystalline structure,remarkable thermal stability,versatile functionality,and biocompatibility,contribute to their significant potential in cancer therapy ap-plications.This review firstly discusses COFs with various morphologies in theranostic applications.The primary morphol-ogies of COFs for tumors treatment can be categorized into four types:nanospheres,nanosheets,nano-rods/tubes and nanoparticles.Furthermore,we review recent research articles and systematically discuss recent advancements in COFs for chemotherapy,chemodynamic therapy,photodynamic therapy,photothermal therapy and combination therapy.In conclusion,we outline the current obstacles and potential future directions for this distinctive research area.

外文关键词：

covalent organic frameworksphotodynamic therapyphotothermal therapycombinatorial therapy

作者：

Junlin Li、Yuanfeng Ye、Yudi Peng、Xiaoyun Hu、Fanjiao Chen、Yifan Zhang、Shengchen Wang、Suli Liu、Dingsheng Wang、Zhihui Dai

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作者单位：

Nanjing Key Laboratory of Optometric Materials and Technology School of Materials and Engineering,Jinling Institute of Technology,Nanjing 211169,China

School of Chemistry and Molecular Engineering,Nanjing Tech University,Nanjing 211816,China

Department of Chemistry Tsinghua University,Beijing 100022,China

关键词：

covalent organic frameworks photodynamic therapy photothermal therapy combinatorial therapy

出版年：

2024

DOI：

10.1360/nso/20240042

国家科学进展(英文)

ISSN：

年,卷(期)：2024.3(6)