首页|Brain circuits for retching-like behavior

Brain circuits for retching-like behavior

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  • NSTL
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Nausea and vomiting are important defensive responses to cope with pathogens and toxins that invade the body.The nucleus of the solitary tract(NTS)is important for initiating these responses.However,the molecular heterogeneities and cellular diversities of the NTS occlude a better understanding of these defensive responses.Here,we constructed the single-nucleus transcriptomic atlas of NTS cells and found multiple populations of NTS neurons that maybe involved in these defensive responses.Among these,we identified Calbindin1-positive(Calb1+)NTS neurons that are molecularly distinct from Tac1+neurons.These Calbl+neurons are critical for nausea and retching induced by cereulide;an emetic toxin secreted by Bacillus Cereus.Strikingly,we found that cereulide can directly modulate vagal sensory neurons that innervate Calb1+NTS neurons,a novel mechanism distinct from that for nausea and retching induced by Staphylococcal enterotoxin A.Together,our transcriptomic atlas of NTS neurons and the functional analyses revealed the neural mechanism for cereulide-induced retching-like behavior.These results demonstrate the molecular and cellular complexities in the brain that underlie defensive responses to the diversities of pathogens and toxins.

vomitingnauseanucleus of the solitary tractCalbindinlneural circuits

Lifang Huo、Zhimin Ye、Meiling Liu、Ziqing He、Meizhu Huang、Dapeng Li、Qian Wu、Qian Wang、Xiaoqun Wang、Peng Cao、Ji Dong、Congping Shang

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School of Basic Medical Sciences,Guangzhou National Laboratory,The Fifth Affiliated Hospital,Guangzhou Medical University,Guangzhou 510799,China

Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory),Guangzhou 510320,China

Department of Neurobiology,School of Basic Medical Sciences,Beijing Key Laboratory of Neural Regeneration and Repair,Advanced Innovation Center for Human Brain Protection,Capital Medical University,Beijing 100069,China

State Key Laboratory of Cognitive Neuroscience and Learning,IDG/McGovern Institute for Brain Research,Beijing Normal University,Beijing 100875,China

Changping Life Science Laboratory,Beijing 102299,China

National Institute of Biological Sciences,Beijing 102206,China

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National Key R&D Program of ChinaNational Natural Science Foundation of ChinaResearch Foundation for Advanced Talents from Guangzhou National LaboratoryBioland LaboratoryYoung Elite Scientist Sponsorship Program by CASTChina Postdoctoral Science Foundation fellowship

ST12030-Major Projects-2021ZD020240032271069YW-JCYJ06031102101217YESS20200122PDXM29424801

2024

10.1093/nsr/nwad256

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ISSN：
年,卷(期)：2024.11(1)
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