首页|Solid-state atomic hydrogen as a broad-spectrum RONS scavenger for accelerated diabetic wound healing

Solid-state atomic hydrogen as a broad-spectrum RONS scavenger for accelerated diabetic wound healing

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Hydrogen therapy shows great promise as a versatile treatment method for diseases associated with the overexpression of reactive oxygen and nitrogen species(RONS).However,developing an advanced hydrogen therapy platform that integrates controllable hydrogen release,efficient RONS elimination,and biodegradability remains a giant technical challenge.In this study,we demonstrate for the first time that the tungsten bronze phase H0.53WO3(HWO)is an exceptionally ideal hydrogen carrier,with salient features including temperature-dependent highly-reductive atomic hydrogen release and broad-spectrum RONS scavenging capability distinct from that of molecular hydrogen.Moreover,its unique pH-responsive biodegradability ensures post-therapeutic clearance at pathological sites.Treatment with HWO of diabetic wounds in an animal model indicates that the solid-state atomic H promotes vascular formation by activating M2-type macrophage polarization and anti-inflammatory cytokine production,resulting in acceleration of chronic wound healing.Our findings significantly expand the basic categories of hydrogen therapeutic materials and pave the way for investigating more physical forms of hydrogen species as efficient RONS scavengers for clinical disease treatment.

atomic hydrogenRONS scavengerinflammatory regulationdiabetic wound healinghydrogen therapy

Man Luo、Qin Wang、Gang Zhao、Wei Jiang、Cici Zeng、Qingao Zhang、Ruyu Yang、Wang Dong、Yunxi Zhao、Guozhen Zhang、Jun Jiang、Yucai Wang、Qing Zhu

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Key Laboratory of Precision and Intelligent Chemistry,School of Chemistry and Materials Science,University of Science and Technology of China,Hefei 230026,China

Department of Radiology,The First Affiliated Hospital of University of Science and Technology of China,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230026,China

Shenzhen Senior High School,Shenzhen 518040,China

Institute of Intelligent Innovation,Henan Academy of Sciences,Zhengzhou 451162,China

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Innovation Program for Quantum Science and TechnologyChinese Academy of Sciences(CAS)Project for Young Scientists in Basic ResearchNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaAnhui Provincial Natural Science Foundation

2021ZD0303303YSBR-0052202530422033007520250362163300722103076522731562108085QB63

2024

10.1093/nsr/nwad269

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ISSN：
年,卷(期)：2024.11(2)
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