首页|Bright,photostable and long-circulating NIR-Ⅱnanoparticles for whole-process monitoring and evaluation of renal transplantation

Bright,photostable and long-circulating NIR-Ⅱnanoparticles for whole-process monitoring and evaluation of renal transplantation

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Kidney transplantation is the gold standard for the treatment of end-stage renal diseases(ESRDs).However,the scarcity of donor kidneys has caused more and more ESRD patients to be stuck on the waiting list for transplant surgery.Improving the survival rate for renal grafts is an alternative solution to the shortage of donor kidneys.Therefore,real-time monitoring of the surgical process is crucial to the success of kidney transplantation,but efficient methods and techniques are lacking.Herein,a fluorescence technology based on bright,photostable and long-circulating aggregation-induced emission(AIE)active NIR-Ⅱnano-contrast agent DIPT-ICF nanoparticles for the whole-process monitoring and evaluation of renal transplantation has been reported.In the aggregated state,DIPT-ICF exhibits superior photophysical properties compared with the commercial dyes IR-26 and IR-1061.Besides,the long-circulating characteristic of the AIE nano-contrast agent helps to achieve renal angiography in kidney retrieval surgery,donor kidney quality evaluation,diagnosing vascular and ureteral complications,and assessment of renal graft reperfusion beyond renovascular reconstruction,which considerably outperforms the clinically approved indocyanine green(ICG).

aggregation-induced emissionNIR-Ⅱ imagingkidney transplantationnano-contrast agentangiography

Rongyuan Zhang、Ping Shen、Yu Xiong、Tianjing Wu、Gang Wang、Yucheng Wang、Liping Zhang、Han Yang、Wei He、Jian Du、Xuedong Wei、Siwei Zhang、Zijie Qiu、Weijie Zhang、Zheng Zhao、Ben Zhong Tang

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Clinical Translational Research Center of Aggregation-Induced Emission,The Second Affiliated Hospital,School of Medicine,School of Science and Engineering,Shenzhen Institute of Aggregate Science and Technology,The Chinese University of Hong Kong,Shenzhen(CUHK-Shenzhen),Shenzhen 518172,China

Center for AIE Research,Shenzhen Key Laboratory of Polymer Science and Technology,Guangdong Research Center for Interfacial Engineering of Functional Materials,College of Materials Science and Engineering,Shenzhen Univer

School of Chemistry,Xiangtan University,Xiangtan 411105,China

Center for AIE Research,Shenzhen Key Laboratory of Polymer Science and Technology,Guangdong Research Center for Interfacial Engineering of Functional Materials,College of Materials Science and Engineering,Shenzhen University,Shenzhen 518061,China

HKUST-Shenzhen Research Institute,Shenzhen 518057,China

Department of Chemistry,Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction,The Hong Kong University of Science and Technology,Hong Kong,China

Department of Urology,The First Affiliated Hospital of Soochow University,Suzhou 215006,China

AIE Institute,Guangzho

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National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Key Research and Development Program of ChinaShenzhen Key Laboratory of Functional Aggregate MaterialsShenzhen Key Laboratory of Functional Aggregate MaterialsShenzhen Key Laboratory of Functional Aggregate MaterialsShenzhen Key Laboratory of Functional Aggregate MaterialsShenzhen Key Laboratory of Functional Aggregate MaterialsInnovation and Technology Commission

5200322852273197217881022023YFB3810001ZDSYS20211021111400001JCYJ20220818103007014JCYJ2021324134613038KQTD20210811090142053JSGG20220606ITC-CNERC14SC01

2024

10.1093/nsr/nwad286

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ISSN：
年,卷(期)：2024.11(2)
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