首页|Liquid metal biomaterials:translational medicines,challenges and perspectives

Liquid metal biomaterials:translational medicines,challenges and perspectives

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Until now,significant healthcare challenges and growing urgent clinical requirements remain incompletely addressed by presently available biomedical materials.This is due to their inadequate mechanical compatibility,suboptimal physical and chemical properties,susceptibility to immune rejection,and concerns about long-term biological safety.As an alternative,liquid metal(LM)opens up a promising class of biomaterials with unique advantages like biocompatibility,flexibility,excellent electrical conductivity,and ease of functionalization.However,despite the unique advantages and successful explorations of LM in biomedical fields,widespread clinical translations and applications of LM-based medical products remain limited.This article summarizes the current status and future prospects of LM biomaterials,interprets their applications in healthcare,medical imaging,bone repair,nerve interface,and tumor therapy,etc.Opportunities to translate LM materials into medicine and obstacles encountered in practices are discussed.Following that,we outline a blueprint for LM clinics,emphasizing their potential in making new-generation artificial organs.Last,the core challenges of LM biomaterials in clinical translation,including bio-safety,material stability,and ethical concerns are also discussed.Overall,the current progress,translational medicine bottlenecks,and perspectives of LM biomaterials signify their immense potential to drive future medical breakthroughs and thus open up novel avenues for upcoming clinical practices.

liquid metal biomaterialstranslational medicineclinical devicehealthcaretherapeutics

Hanchi Xu、Jincheng Lu、Yikuang Xi、Xuelin Wang、Jing Liu

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Department of Biomedical Engineering,School of Medicine,Tsinghua University,Beijing 100084,China

Beijing Tsinghua Changgung Hospital,School of Clinical Medicine,Tsinghua University,Beijing 102218,China

Shanghai World Foreign Language Academy,Shanghai 200233,China

Beijing Advanced Innovation Center for Biomedical Engineering,School of Engineering Medicine,Beihang University,Beijing 100191,China

Beijing Key Lab of Cryo-Biomedical Engineering and Key Lab of Cryogenics,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing 100190,China

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National Natural Science Foundation of ChinaBeijing National Science FoundationTsinghua University Initiative Scientific Research Program of Prevision Medicine

51890893KZ72016801

2024

10.1093/nsr/nwad302

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ISSN：
年,卷(期)：2024.11(2)
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