首页|Allelic reprogramming of chromatin states in human early embryos

Allelic reprogramming of chromatin states in human early embryos

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The reprogramming of parental epigenomes in human early embryos remains elusive.To what extent the characteristics of parental epigenomes are conserved between humans and mice is currently unknown.Here,we mapped parental haploid epigenomes using human parthenogenetic and androgenetic embryos.Human embryos have a larger portion of genome with parentally specific epigenetic states than mouse embryos.The allelic patterns of epigenetic states for orthologous regions are not conserved between humans and mice.Nevertheless,it is conserved that maternal DNA methylation and paternal H3K27me3 are associated with the repression of two alleles in humans and mice.In addition,for DNA-methylation-dependent imprinting,we report 19 novel imprinted genes and their associated germline differentially methylated regions.Unlike in mice,H3K27me3-dependent imprinting is not observed in human early embryos.Collectively,allele-specific epigenomic reprogramming is different in humans and mice.

human embryoepigenetics reprogrammingDNA methylationH3K27me3chromatin accessibility

Shenli Yuan、Lei Gao、Wenrong Tao、Jianhong Zhan、Gang Lu、Jingye Zhang、Chuanxin Zhang、Lizhi Yi、Zhenbo Liu、Zhenzhen Hou、Min Dai、Han Zhao、Zi-Jiang Chen、Jiang Liu、Keliang Wu

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Center for Reproductive Medicine,Shandong University,Jinan 250012,China

CAS Key Laboratory of Genome Sciences and Information,Collaborative Innovation Center of Genetics and Development,Beijing Institute of Genomics,and China National Center for Bioinformation,Chinese Academy of Sciences,Beijing 100101,China

University of Chinese Academy of Sciences,Beijing 100049,China

CUHK-SDU Joint Laboratory on Reproductive Genetics,School of Biomedical Sciences,the Chinese University of Hong Kong,Hong Kong,China

Key Laboratory of Reproductive Endocrinology of the Ministry of Education,Shandong University,Jinan 250012,China

Center for Reproductive Medicine,Ren Ji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200135,China

CAS Center for Excellence in Animal Evolution and Genetics,Chinese Academy of Sciences,Kunming 650223,China

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国家重点研发计划Basic Science Center Program of National Natural Science Foundation of China(NSFC)国家自然科学基金国家自然科学基金Shandong Provincial Key Research and Development Program中国科学院青年创新促进会项目中央高校基本科研业务费专项山东省"泰山学者"项目Innovative Research Team of High-level Local Universities in Shanghai

2021YFC27003033198810132170817316300402020ZLYS0220200000112022JC006tsqn201909194SHSMU-ZLCX20210201

2024

10.1093/nsr/nwad328

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ISSN：
年,卷(期)：2024.11(3)
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