首页|In-situ synthesis of quantum dots in the nucleus of live cells
In-situ synthesis of quantum dots in the nucleus of live cells
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The cell nucleus is the main site for the storage and replication of genetic material,and the synthesis of substances in the nucleus is rhythmic,regular and strictly regulated by physiological processes.However,whether exogenous substances,such as nanoparticles,can be synthesized in situ in the nucleus of live cells has not been reported.Here,we have achieved in-situ synthesis of CdSxSe1-x quantum dots(QDs)in the nucleus by regulation of the glutathione(GSH)metabolic pathway.High enrichment of GSH in the nucleus can be accomplished by the addition of GSH with the help of the Bcl-2 protein.Then,high-valence Se is reduced to low-valence Se by glutathione-reductase-catalyzed GSH,and interacts with the Cd precursor formed through Cd and thiol-rich proteins,eventually generating QDs in the nucleus.Our work contributes to a new understanding of the syntheses of substances in the cell nucleus and will pave the way for the development of advanced'supercells'.
Yusi Hu、Zhi-Gang Wang、Haohao Fu、Chuanzheng Zhou、Wensheng Cai、Xueguang Shao、Shu-Lin Liu、Dai-Wen Pang
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State Key Laboratory of Medicinal Chemical Biology,Frontiers Science Centre for New Organic Matter,Tianjin Key Laboratory of Biosensing and Molecular Recognition,Research Centre for Analytical Sciences,College of Chemistry,School of Medicine,and Frontiers Science Centre for Cell Responses,Nankai University,Tianjin 300071,China
Haihe Laboratory of Sustainable Chemical Transformations,Tianjin 300192,China
国家自然科学基金国家自然科学基金国家自然科学基金国家重点研发计划中央高校基本科研业务费专项Haihe Laboratory of Sustainable Chemical Transformations
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