Bioinspired polysaccharide-based nanocomposite membranes with robust wet mechanical properties for guided bone regeneration

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外文摘要：Polysaccharide-based membranes with excellent mechanical properties are highly desired.However,severe mechanical deterioration under wet conditions limits their biomedical applications.Here,inspired by the structural heterogeneity of strong yet hydrated biological materials,we propose a strategy based on heterogeneous crosslink-and-hydration(HCH)of a molecule/nano dual-scale network to fabricate polysaccharide-based nanocomposites with robust wet mechanical properties.The heterogeneity lies in that the crosslink-and-hydration occurs in the molecule-network while the stress-bearing nanofiber-network remains unaffected.As one demonstration,a membrane assembled by bacterial cellulose nanofiber-network and Ca2+-crosslinked and hydrated sodium alginate molecule-network is designed.Studies show that the crosslinked-and-hydrated molecule-network restricts water invasion and boosts stress transfer of the nanofiber-network by serving as interfibrous bridge.Overall,the molecule-network makes the membrane hydrated and flexible;the nanofiber-network as stress-bearing component provides strength and toughness.The HCH dual-scale network featuring a cooperative effect stimulates the design of advanced biomaterials applied under wet conditions such as guided bone regeneration membranes.

外文关键词：

bioinspirationheterogeneous crosslink-and-hydrationdual-scale networknanocomposite membranewet mechanical propertiesguided bone regeneration

作者：

Jian-Hong Xiao、Zhen-Bang Zhang、JiaHao Li、Si-Ming Chen、Huai-Ling Gao、YinXiu Liao、Lu Chen、ZiShuo Wang、YiFan Lu、YuanZhen Hou、HengAn Wu、DuoHong Zou、Shu-Hong Yu

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作者单位：

Department of Chemistry,New Cornerstone Science Laboratory,Institute of Biomimetic Mateiials &Chemistry,Anhui Engineering Laboratory of Biomimetic Materials,Division of Nanomaterials& Chemistry,Hefei National Research Center for Physical Sciences at the Microscale,University of Science and Technology of China,Hefei 230026,China

Department of Dental Implant Center,Stomatologic Hospital and College,Key Laboratory of Oral Diseases Research of Anhui Province,Anhui Medical University,Hefei 230032,China

CAS Key Laboratory of Mechanical Behavior and Design of Materials,Department of Modern Mechanics,CAS Center for Excellence in Complex System Mechanics,University of Science and Technology of China,Hefei 230027,China

CAS Key Laboratory of Mechanical Behavior and Design of Materials,Department of Modern Mechanics,CAS Center for Excellence in Complex System Mechanics,University of Science and Techn

Department of Oral Surgery,College of Stomatology,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology,Shanghai Research Institute of Stomatology,Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200001,China

Institute of Innovative Materials(I2M),Department of Chemistry,Department of Materials Science and Engineering,Southern University of Science and Technology,Shenzhen 518055,China

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基金：

国家重点研发计划国家重点研发计划国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金Major Basic Research Project of Anhui ProvinceUniversity of Science and Technology of China(USTC)Research Funds of the Double First-Class Initiative

项目编号：

2021YFA07157002018YFE020220122293044U19322133217134722005289922631022023z04020009YD9990002019

出版年：

2024

DOI：

10.1093/nsr/nwad333

国家科学评论(英文版)

CSTPCD

ISSN：

年,卷(期)：2024.11(3)

参考文献量63