Control of defensive behavior by the nucleus of Darkschewitsch GABAergic neurons

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外文摘要：The nucleus of Darkschewitsch(ND),mainly composed of GABAergic neurons,is widely recognized as a component of the eye-movement controlling system.However,the functional contribution of ND GABAergic neurons(NDGABA)in animal behavior is largely unknown.Here,we show that NDGABA neurons were selectively activated by different types of fear stimuli,such as predator odor and foot shock.Optogenetic and chemogenetic manipulations revealed that NDGABA neurons mediate freezing behavior.Moreover,using circuit-based optogenetic and neuroanatomical tracing methods,we identified an excitatory pathway from the lateral periaqueductal gray(1PAG)to the ND that induces freezing by exciting ND inhibitory outputs to the motor-related gigantocellular reticular nucleus,ventral part(GiV).Together,these findings indicate the NDGABA population as a novel hub for controlling defensive response by relaying fearful information from the 1PAG to GiV,a mechanism critical for understanding how the freezing behavior is encoded in the mammalian brain.

外文关键词：

nucleus of DarkschewitschGABAergic populationdefensive behaviorfreezingneural circuitry

作者：

Huiying Zhao、Jinrong Liu、Yujin Shao、Xiang Feng、Binhan Zhao、Li Sun、Yijun Liu、Linghui Zeng、Xiao-ming Li、Hongbin Yang、Shumin Duan、Yan-qin Yu

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作者单位：

Department of Neurology of Second Affiliated Hospital and School of Brain Science and Brain Medicine,Zhejiang University School of Medicine,Hangzhou 310058,China

Nanhu Brain-Computer Interface Institute,Hangzhou 311100,China

Liangzhu Laboratory,MOE Frontier Science Center for Brain Science and Brain-Machine Integration,State Key Laboratory of Brain-Machine Intelligence,Zhejiang University,Hangzhou 311121,China

NHC and CAMS Key Laboratory of Medical Neurobiology,Zhejiang University,Hangzhou 310058,China

Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province,School of Medicine,Hangzhou City University,Hangzhou 310015,China

Key Laboratory of Novel Targets and Drug Study for Neural Repair of

Key

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基金：

ST12030-Major Projects国家自然科学基金重大项目国家自然科学基金重大项目国家自然科学基金重大项目国家自然科学基金重大项目国家自然科学基金重大项目国家自然科学基金重大项目浙江省自然科学基金浙江省自然科学基金浙江省重点研发计划CAMS Innovation Fund for Medical SciencesNon-Profit Central Research Institute Fund of the Chinese Academy of Medical Sciences

项目编号：

2021ZD0203400T2293733T2293730319709398228810182090033U20A6005LZ22H090001LR24C0900012022C030342019-I2M-5-0572023-PT310-01

出版年：

2024

DOI：

10.1093/nsr/nwae082

国家科学评论(英文版)

CSTPCD

ISSN：

年,卷(期)：2024.11(4)

参考文献量66