首页|The flattening of spacetime hierarchy of the N,N-dimethyltryptamine brain state is characterized by harmonic decomposition of spacetime(HADES)framework

The flattening of spacetime hierarchy of the N,N-dimethyltryptamine brain state is characterized by harmonic decomposition of spacetime(HADES)framework

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The human brain is a complex system,whose activity exhibits flexible and continuous reorganization across space and time.The decomposition of whole-brain recordings into harmonic modes has revealed a repertoire of gradient-like activity patterns associated with distinct brain functions.However,the way these activity patterns are expressed over time with their changes in various brain states remains unclear.Here,we investigate healthy participants taking the serotonergic psychedelic N,N-dimethyltryptamine(DMT)with the Harmonic Decomposition of Spacetime(HADES)framework that can characterize how different harmonic modes defined in space are expressed over time.HADES demonstrates significant decreases in contributions across most low-frequency harmonic modes in the DMT-induced brain state.When normalizing the contributions by condition(DMT and non-DMT),we detect a decrease specifically in the second functional harmonic,which represents the uni-to transmodal functional hierarchy of the brain,supporting the leading hypothesis that functional hierarchy is changed in psychedelics.Moreover,HADES'dynamic spacetime measures of fractional occupancy,life time and latent space provide a precise description of the significant changes of the spacetime hierarchical organization of brain activity in the psychedelic state.

spatio-temporal brain dynamicsDMTharmonic modes

Jakub Vohryzek、Joana Cabral、Christopher Timmermann、Selen Atasoy、Leor Roseman、David J.Nutt、Robin L.Carhart-Harris、Gustavo Deco、Morten L.Kringelbach

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Centre for Eudaimonia and Human Flourishing,Linacre College,Department of Psychiatry,University of Oxford,Oxford OX39BX,UK

Department of Psychiatry,University of Oxford,Oxford OX3 7JX,UK

Center for Music in the Brain,Aarhus University,Aarhus 8000,Denmark

Center for Brain and Cognition,Computational Neuroscience Group,Department of Information and Communication Technologies,Universitat Pompeu Fabra,Barcelona 08005,Spain

Life and Health Sciences Research Institute,School of Medicine,University of Minho,Braga 4710-057,Portugal

ICVS/3B's-PT Government Associate Laboratory,Braga/Guimarães 4710-057,Portugal

Centre for Psychedelic Research,Department of Brain Sciences,Imperial College London,London SW7 2AZ,UK

Departments of Neurology and Psychiatry,University of California San Francisco,San Francisco 94143,USA

Institució Catalana de la Recerca i Estudis Avançats(ICREA),Barcelona 08010,Spain

Department of Neuropsychology,Max Planck Institute for Human Cognitive and Brain Sciences,Leipzig,Germany

School of Psychological Sciences,Monash University,Melbourne,Australia

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EU H FET Proactive project Neurotwin(2020)European Research Council Consolidator GrantPettit Foundation,Carlsberg Foundation,Center for Music in the BrainDanish National Research Foundationla Caixa'Foundation,SpainPortuguese Foundation for Science and Technology,PortugalPortuguese Foundation for Science and Technology,PortugalSpanish Research ProjectAgencia Estatal de Investigación/Fondo Europeo de Desarrollo Regional,European UnionEuropean Union's Horizon research and innovation programme(2020)European Union's Horizon research and innovation programme(2020)Catalan Agency for Management of University and Research Grants

101017716615539DNRF117LCF/BQ/PR22/11920014UIDB/50026/2020UIDP/50026/2020PSI2016-75688-P720270Human Brain Project[HBP]SGA1785907HBP SGA22017 SGR 1545

2024

10.1093/nsr/nwae124

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年,卷(期)：2024.11(5)
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