首页|Biomaterial design for regenerating aged bone:materiobiological advances and paradigmatic shifts

Biomaterial design for regenerating aged bone:materiobiological advances and paradigmatic shifts

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China's aging demographic poses a challenge for treating prevalent bone diseases impacting life quality.As bone regeneration capacity diminishes with age due to cellular dysfunction and inflammation,advanced biomaterials-based approaches offer hope for aged bone regeneration.This review synthesizes materiobiology principles,focusing on biomaterials that target specific biological functions to restore tissue integrity.It covers strategies for stem cell manipulation,regulation of the inflammatory microenvironment,blood vessel regeneration,intervention in bone anabolism and catabolism,and nerve regulation.The review also explores molecular and cellular mechanisms underlying aged bone regeneration and proposes a database-driven design process for future biomaterial development.These insights may also guide therapies for other age-related conditions,contributing to the pursuit of'healthy aging'.

materiobiologybiomaterial designagingbone regenerationartificial intelligence

戴凯、耿振、张文超、魏雪、王靖、聂广军、刘昌胜

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Engineering Research Center for Biomedical Materials of the Ministry of Education,East China University of Science and Technology,Shanghai 200237,China

State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai 200237,China

Frontiers Science Center for Materiobiology and Dynamic Chemistry,East China University of Science and Technology

Shanghai 200237,China

Key Laboratory for Ultrafine Materials of the Ministry of Education,East China University of Science and Te

Institute of Translational Medicine,Shanghai University,Shanghai 200444,China

National Center for Translational Medicine (Shanghai)SHU Branch,Shanghai University,Shanghai 200444,China

CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety,CAS Centre for Excellence in Nanoscience,National Centre for Nanoscience and Technology,Beijing 100190,China

Center of Materials Science and Optoelectronics Engineering,University of Chinese Academy of Sciences,Beijing 100049,China

Key Laboratory for Ultrafine Materials of the Ministry of Education,East China University of Science and Technology,Shanghai 200237,China

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Basic Science Center Program国家自然科学基金重点项目国家自然科学基金Foundation of Frontiers Science Center for Materiobiology and Dynamic ChemistryWego Project of Chinese Academy of Sciences中国博士后科学基金

T22881023223005932301123JKVD121100220200052022M721147

2024

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ISSN:
年,卷(期):2024.11(5)
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