Superparamagnetic iron oxide nanoparticle regulates microbiota-gut-inner ear axis for hearing protection

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外文摘要：Noise-induced hearing loss(NIHL)is a highly prevalent form of sensorineural hearing damage that has significant negative effects on individuals of all ages and there are no effective drugs approved by the US Food and Drug Administration.In this study,we unveil the potential of superparamagnetic iron oxide nanoparticle assembly(SPIOCA)to reshape the dysbiosis of gut microbiota for treating NIHL.This modulation inhibits intestinal inflammation and oxidative stress responses,protecting the integrity of the intestinal barrier.Consequently,it reduces the transportation of pathogens and inflammatory factors from the bloodstream to the cochlea.Additionally,gut microbiota-modulated SPIOCA-induced metabolic reprogramming in the gut-inner ear axis mainly depends on the regulation of the sphingolipid metabolic pathway,which further contributes to the restoration of hearing function.Our study confirms the role of the microbiota-gut-inner ear axis in NIHL and provides a novel alternative for the treatment of NIHL and other microbiota dysbiosis-related diseases.

外文关键词：

superparamagnetic iron oxide nanoparticlehearing lossgut microbiotainflammationsphingolipid metabolismmicrobiota-gut-inner ear axis

作者：

Zhanhang Guo、Yunhao Wu、Bo Chen、Mengdie Kong、Peng Xie、Yan Li、Dongfang Liu、Renjie Chai、Ning Gu

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作者单位：

Jiangsu Key Laboratory for Biomaterialsand Devices,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210009,China

Medical Science and Technology Innovation Center,Shandong First Medical University &Shandong Academy of Medical Sciences,Jinan 250000,China

State Key Laboratory of Digital Medical Engineering,Department of Otolaryngology Head and Neck Surgery,Zhongda Hospital,School of Life Sciences and Technology,School of Medicine,Advanced Institute for Life and Health,Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research,Southeast University,Nanjing 210096,China

Institute of Materials Science and Devices,School of Materials Science and Engineering,Suzhou University of Science and Technology,Suzhou 215009,China

Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging &Interventional Radiology & Vascular Surgery,Department of Radiology,Medical School,Zhongda Hospital,Southeast University,Nanjing 210009,China

Co-lnnovation Center of Neuroregeneration,Nantong University,Nantong 226001,China

School of Medical Technology,Institute of Engineering Medicine,Beijing Institute of Technology,Beijing 1

Cardiovascular Disease Research Center,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Medical School,Nanjing University,Nanjing 210093,China

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基金：

National Key R&D Program of ChinaNational Key R&D Program of ChinaNational Key R&D Program of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNatural Science Foundation of Jiangsu ProvinceNanjing Science and Technology Development FoundationKey Research and Development Program of Jiangsu ProvinceScience and Technology Department of Sichuan ProvinceShenzhen Science and Technology ProgramShenzhen Science and Technology Program2022 Open Project Fund of Guangdong Academy of Medical SciencesNatural Science Foundation for Excellent Youth Scholars of Jiangsu Science

项目编号：

2021YFA11013002021YFA11018002020YFA011250382101228518320016182100282330033820300299214930422108187BK20222002202205066BE20223942021YFS0371JCYJ20190814093401920JCYJ20210324125608022YKY-KF202201BK20230073

出版年：

2024

DOI：

10.1093/nsr/nwae100

国家科学评论(英文版)

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ISSN：

年,卷(期)：2024.11(6)