首页|A low-swelling hydrogel as a multirole sealant for efficient dural defect sealing and prevention of postoperative adhesion

A low-swelling hydrogel as a multirole sealant for efficient dural defect sealing and prevention of postoperative adhesion

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Dural defects and subsequent complications,including cerebrospinal fluid(CSF)leakage,are common in both spine surgery and neurosurgery,and existing clinical treatments are still unsatisfactory.In this study,a tissue-adhesive and low-swelling hydrogel sealant comprising gelatin and o-phthalaldehyde(OPA)-terminated 4-armed poly(ethylene glycol)(4aPEG-OPA)is developed via the OPA/amine condensation reaction.The hydrogel shows an adhesive strength of 79.9±12.0 kPa on porcine casing and a burst pressure of208.0±38.0 cmH2O.The hydrogel exhibits a low swelling ratio at physiological conditions,avoiding nerve compression in the limited spinal and intracranial spaces.In rat and rabbit models of lumbar and cerebral dural defects,the 4aPEG-OPA/gelatin hydrogel achieves excellent performance in dural defect sealing and preventing CSF leakage.Moreover,local inflammation,epidural fibrosis and postoperative adhesion in the defect areas are markedly reduced.Thus,these findings establish the strong potential of the hydrogel sealant for the effective watertight closure of dural defects.

hydrogel sealantwatertight closurelow swellingo-phthalaldehyde chemistrydural sealing

Xueliang Cheng、Zhen Zhang、Hui Ren、Zheng Zou、Yu Zhang、Yang Qu、Xuesi Chen、Jianwu Zhao、Chaoliang He

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CAS Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China

Department of Orthopedics,The Second Norman Bethune Hospital of Jilin University,Changchun 130014,China

School of Applied Chemistry and Engineering,University of Science and Technology of China,Hefei 230026,China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaScientific and Technological Development Projects of Jilin ProvinceJilin Province Youth Science and Technology Talent Support ProjectRural and Social Development Branch,Changchun Science and Technology Bureau

52173147519732182210519820210204136YYQT20221421ZGY23

2024

10.1093/nsr/nwae160

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ISSN：
年,卷(期)：2024.11(6)