Autocatalytic bifunctional supramolecular hydrogels for osteoporotic bone repair

扫码查看

原文链接

NETL
NSTL
万方数据

外文摘要：Conventional bone scaffolds,which are mainly ascribed to highly active osteoclasts and an inflammatory microenvironment with high levels of reactive oxygen species and pro-inflammatory factors,barely satisfy osteoporotic defect repair.Herein,multifunctional self-assembled supramolecular fiber hydrogels(Ce-Aln gel)consisting of alendronate(Aln)and cerium(Ce)ions were constructed for osteoporotic bone defect repair.Based on the reversible interaction and polyvalent cerium ions,the Ce-Aln gel,which was mainly composed of ionic coordination and hydrogen bonds,displayed good injectability and autocatalytic amplification of the antioxidant effect.In vitro studies showed that the Ce-Aln gel effectively maintained the biological function of osteoblasts by regulating redox homeostasis and improved the inflammatory microenvironment to enhance the inhibitory effect on osteoclasts.Ribonucleic acid(RNA)sequencing further revealed significant downregulation of various metabolic pathways,including apoptosis signaling,hypoxia metabolism and tumor necrosis factor-alpha(TNF-a)signaling via the nuclear factor kappa-B pathway after treatment with the Ce-Aln gel.In vivo experiments showed that the clinical drug-based Ce-Aln gel effectively promoted the tissue repair of osteoporotic bone defects by improving inflammation and inhibiting osteoclast formation at the defect.Notably,in vivo systemic osteoporosis was significantly ameliorated,highlighting the strong potential of clinical translation for precise therapy of bone defects.

外文关键词：

autocatalysissupramolecular hydrogelanti-inflammationosteoporosisbone defect

作者：

Zhihui Han、Xiang Gao、Yuanjie Wang、Cheng Huang、Hao Song、Shuning Cheng、Xiaoyuan Yang、Xiaoliang Cui、Jie Wu、Kailu Wei、Liang Cheng

展开 >

作者单位：

Institute of Functional Nano &Soft Materials(FUNSOM),Collaborative Innovation Center of Suzhou Nano Science and Technology,Soochow University,Suzhou 215123,China

Department of Orthopedics,The Second Affiliated Hospital of Soochow University,Suzhou 215004,China

Macao Institute of Materials Science and Engineering,Macau University of Science and Technology,Taipa 999078,China

基金：

National Key R&D Program of ChinaNational Key R&D Program of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaCollaborative Innovation Center of Suzhou Nano Science and Technology,Suzhou Key Laboratory of Nanotechnology and BiomedicinJiangsu Key Laboratory for Carbon-Based Functional Materials &Devices,Soochow UniversityOverseas Expertise Introduction Project for Discipline Innovation(111 Project)Joint International Research Laboratory of Carbon-Based Functional Materials and Devices,Suzhou Key Laboratory of NanotechnoKey Laboratory of Structural Deformities in Children of Suzhou

项目编号：

2022YFB38046002021YFF0701800U20A2025452072253BK20211544KJS2212SZS2022018

出版年：

2024

DOI：

10.1093/nsr/nwae209

国家科学评论(英文版)

CSTPCD

ISSN：

年,卷(期)：2024.11(7)