首页|A highly-selective biomimetic potassium channel

A highly-selective biomimetic potassium channel

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Reproducing the outstanding selectivity achieved by biological ion channels in artificial channel systems can revolutionize applications ranging from membrane filtration to single-molecule sensing technologies,but achieving this goal remains a challenge.Herein,inspired by the selectivity filter structure of the KcsA potassium channel,we propose a design of biomimetic potassium nanochannels by functionalizing the wall of carbon nanotubes with an array of arranged carbonyl oxygen atoms.Our extensive molecular dynamics simulations show that the biomimetic nanochannel exhibits a high K+permeation rate along with a high K+/Na+selectivity ratio.The free energy calculations suggest that the low Na+permeability is the result of the higher energy barrier for Na+than K+at the channel entrance and ion binding sites.In addition,reducing the number of ion binding sites leads to an increase in the permeation rate but a decrease in selectivity.These findings not only hold promise for the design of high-performance membranes but also help understand the mechanism of selective ion transport in biological ion channels.

biomimetic designcarbon nanotubeK+/Na+selectivitymolecular dynamics simulations

Junliang Zhu、Hu Qiu、Wanlin Guo

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Key Laboratory for Intelligent Nano Materials and Devices of the Ministry of Education,State Key Laboratory of Mechanics and Control for Aerospace Structures,Institute for Frontier Science,Nanjing University of Aeronautics and Astronautics,Nanjing 210016,China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNatural Science Foundation of Jiangsu ProvinceNatural Science Foundation of Jiangsu ProvinceNatural Science Foundation of Jiangsu ProvinceNational Key Research and Development Program of ChinaResearch Fund of National Key Laboratory of Mechanics and Control for Aerospace StructuresResearch Fund of National Key Laboratory of Mechanics and Control for Aerospace StructuresFundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central UniversitiesFund of Prospective Layout of Scientific Research for Nanjing University of Aeronautics and Astronautics(NUAA)

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2024

10.1093/nsr/nwae242

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ISSN：
年,卷(期)：2024.11(8)