Nanorepair medicine for treatment of organ injury

扫码查看

原文链接

万方数据
维普

外文摘要：Organ injuries,such as acute kidney injury,ischemic stroke,and spinal cord injury,often result in complications that can be life-threatening or even fatal.Recently,many nanomaterials have emerged as promising agents for repairing various organ injuries.In this review,we present the important developments in the field of nanomaterial-based repair medicine,herein referred to as'nanorepair medicine'.We first introduce the disease characteristics associated with different types of organ injuries and highlight key examples of relevant nanorepair medicine.We then provide a summary of existing strategies in nanorepair medicine,including organ-targeting methodologies and potential countermeasures against exogenous and endogenous pathologic risk factors.Finally,we offer our perspectives on current challenges and future expectations for the advancement of nanomedicine designed for organ injury repair.

外文关键词：

nanomedicineorgan injuryreactive oxygen speciesinflammationdrug administration

作者：

Han Wang、Jessica C.Hsu、Wenyu Song、Xiaoli Lan、Weibo Cai、Dalong Ni

展开 >

作者单位：

Department of Orthopaedics,Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases,Shanghai Institute of Traumatology and Orthopaedics,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China

Departments of Radiology and Medical Physics,University of Wisconsin-Madison,Madison,WI 53705,USA

Department of Nuclear Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430073,China

Hubei Province Key Laboratory of Molecular Imaging,Wuhan 430022,China

Key Laboratory of Biological Targeted Therapy of the Ministry of Education,Wuhan 430073,China

展开 >

基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaOpening Project of State Key Laboratory of High Performance Ceramics and Superfine MicrostructureUniversity of Wisconsin-MadisonNational Institutes of HealthNational Institutes of Health

项目编号：

823720988210219082030052SKL202212SICP30CA014520T32CA009206

出版年：

2024

DOI：

10.1093/nsr/nwae280

国家科学评论(英文版)

CSTPCD

ISSN：

年,卷(期)：2024.11(9)