It is meaningful and necessary to combine the construction of key discipline with undergraduate education to improve the quality of undergraduate talent training system.Taking the teaching mode innovation of civil engineering specialty in Henan University as an example,combining with the actual construction of provincial key disciplines,this paper reforms and supplements the original undergraduate talent training scheme,and sixteen specific measures are put forward from two aspects of system construction and innovation and entrepreneurship practice.The feasibility is verified through the tracking investigation and analysis of the reform results in recent four years,and good innovation effect is obtained.