On the basis of analyzing the knowledge characteristics of the course of Airport Operation Management,starting from the optimization of the course teaching module,the design of the teaching process,the construction of the course learning resources,and the course implementation process,the mixed teaching mode of the course of Airport Operation Management based on O2O is constructed through online theoretical learning,classroom case analysis,laboratory simulation training,and enterprise job practice.Finally,according to the exploration practice,the corresponding countermeasures and suggestions are put forward for the implementation of the O2O teaching mode.