SPOC(Small Private Online Course)is a typical curriculum teaching mode in the post-MOOC era.It is characterized by its anti-popularization,restriction,and intensification,aiming to maximize the deep integration between MOOC and traditional classroom teaching.This paper actively explores and establishes a hybrid teaching mode for Physical Chemistry Experiment based on SPOC,online,and offline classroom.It is hoped to provide a reference for the application of SPOC in universities and for the reform of Physical Chemistry Experiment teaching.Practices show that the hybrid teaching mode improves students'abilities in self-learning,teamwork,and scientific research innovation.It can also help optimizing the experimental teaching.