On and offline course process assessment of Engineering Chemistry is the main construction goal of this paper.According to the requirements of teaching syllabus and course assessment,the online and offline mixed assessment is designed.The examination content,examination form and evaluation standard are developed.The feasibility and effectiveness of this mixed course assessment are analyzed.The accelerative function and practicability of course understanding and mastery are analyzed.The study habits of current college students are analyzed by questionnaires.The results show that online assessment has a stimulating effect on learning.Based on the final assessment data,this paper analyzes the auxiliary effect of this mixed assessment mode on the analysis of teachers'learning situation,which provides a reference for exploring the multi-dimensional assessment method of basic subjects.