Wireless sequential dual light delivery for programmed PDT in vivo

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国家科技期刊平台
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外文摘要：Using photodynamic therapy(PDT)to treat deep-seated cancers is limited due to inefficient delivery of photosensitizers and low tissue penetration of light.Polymeric nanocarriers are widely used for photosensitizer delivery,while the self-quenching of the encapsulated photosensitizers would impair the PDT efficacy.Furthermore,the generated short-lived reactive oxygen spieces(ROS)can hardly diffuse out of nanocarriers,resulting in low PDT efficacy.Therefore,a smart nanocarrier system which can be degraded by light,followed by photosensitizer activation can potentially overcome these limitations and enhance the PDT efficacy.A light-sensitive polymer nanocarrier encapsulating photosensitizer(RB-M)was synthesized.An implantable wireless dual wavelength microLED device which delivers the two light wavelengths sequentially was developed to programmatically control the release and activation of the loaded photosensitizer.Two transmitter coils with matching resonant frequencies allow activation of the connected LEDs to emit different wavelengths independently.Optimal irradiation time,dose,and RB-M concentration were determined using an agent-based digital simulation method.In vitro and in vivo validation experiments in an orthotopic rat liver hepatocellular carcinoma disease model confirmed that the nanocarrier rupture and sequential low dose light irradiation strategy resulted in successful PDT at reduced photosensitizer and irradiation dose,which is a clinically significant event that enhances treatment safety.

作者：

Jiayi Liu、Bowen Sun、Wenkai Li、Han-Joon Kim、Shu Uin Gan、John S.Ho、Juwita Norasmara Bte Rahmat、Yong Zhang

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作者单位：

Department of Oncology,The Second Xiangya Hospital,Central South University,Changsha,Hunan 410011,China

Department of Biomedical Engineering,College of Design and Engineering,National University of Singapore,Singapore 117585,Singapore

Department of Mechanical Engineering,College of Design and Engineering,National University of Singapore,Singapore 117576,Singapore

Department of Electrical and Computer Engineering,College of Design and Engineering,National University of Singapore,Singapore 117583,Singapore

Department of Medical IT Convergence Engineering,Kumoh National Institute of Technology,Gumi 39253,Republic of Korea

Department of Surgery,Yong Loo Lin School of Medicine,National University of Singapore,Singapore 119228,Singapore

The N.1 Institute for Health,National University of Singapore,Singapore 117456,Singapore

Institute for Health Innovation and Technology,National University of Singapore,Singapore 119276,Singapore

Department of Biomedical Engineering,College of Engineering,City University of Hong Kong,Kowloon,Hong Kong SAR,China

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基金：

National Medical Research Council,SingaporeNational Medical Research Council,SingaporeNational Medical Research Council,SingaporeCity University of Hong Kong

项目编号：

NMRCMOH-000640MOH-001114-009380160

出版年：

2024

DOI：

10.1038/s41377-024-01437-x

光:科学与应用(英文版)

中国科学院长春光学精密机械与物理研究所

光:科学与应用(英文版)

CSTPCD

ISSN：2095-5545

年,卷(期)：2024.13(6)