首页|Dynamic synthetic-scanning photoacoustic tracking monitors hepatic and renal clearance pathway of exogeneous probes in vivo

Dynamic synthetic-scanning photoacoustic tracking monitors hepatic and renal clearance pathway of exogeneous probes in vivo

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
Advancements in precision medicine necessitate understanding drug clearance pathways,especially in organs like the liver and kidneys.Traditional techniques such as PET/CT pose radiation hazards,whereas optical imaging poses challenges in maintaining both depth penetration and high resolution.Moreover,very few longitudinal studies have been performed for drug candidates for different symptoms.Leveraging non-ionizing photoacoustic tomography for deep tissue imaging,we developed a spatiotemporally resolved clearance pathway tracking(SRCPT)method,providing unprecedented insights into drug clearance dynamics within vital organs.SRCPT addresses challenges like laser fluence attenuation,enabling dynamic visualization of drug clearance pathways and essential parameter extraction.We employed a novel frequency component selection based synthetic aperture focusing technique(FCS-SAFT)with respiratory-artifacts-free weighting factors to enhance three-dimensional imaging resolutions.Inspired by this,we investigated the clearance pathway of a clinical drug,mitoxantrone,revealing reduced liver clearance when hepatic function is impaired.Furthermore,immunoglobulin G clearance analysis revealed significant differences among mice with varying renal injury degrees.The accuracy of our method was validated using a double-labeled probe[68Ga]DFO-IRDye800CW,showing a strong positive correlation between SRCPT and PET.We believe that this powerful SRCPT promises precise mapping of drug clearance pathways and enhances diagnosis and treatment of liver and kidney-related diseases.

Jing Lv、Hengrong Lan、Aoji Qin、Tong Sun、Dan Shao、Fei Gao、Junjie Yao、Kamran Avanaki、Liming Nie

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Guangdong Cardiovascular Institute,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,China

Medical Research Institute,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Southern Medical University,Guangzhou 510080,China

School of Biomedical Engineering,Tsinghua University,Beijing 100084,China

Department of PET Center,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Southern Medical University,Guangzhou 510080,China

Hybrid Imaging System Laboratory,School of Information Science and Technology,ShanghaiTech University,Shanghai 201210,China

Department of Biomedical Engineering,Duke University,Durham,NC 27708,USA

Richard and Loan Hill Department of Biomedical Engineering,University of Illinois at Chicago,Chicago,IL 60607,USA

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2024

10.1038/s41377-024-01644-6

光:科学与应用(英文版)
中国科学院长春光学精密机械与物理研究所

光:科学与应用(英文版)

CSTPCD
ISSN：2095-5545
年,卷(期)：2024.13(12)