Preparation and characterization of betaine-type gelatin hydrogels with high light transmittance
Due to the poor light transmission,anti-protein adsorption capacity and flexibility,methacryloylated gelatin(GelMA)hydrogel is limited in artificial cornea.This paper aims to introduce methacryloxyethyl sulfo-betaine(SBMA)with excellent bioadsorption resistance and outstanding biocompatibility to GelMA hydrogel,and construct a series of zwitterionic hydrogel GelMA-SBMA system.The physicochemical and biological prop-erties of hydrogels are discussed,and the vitro cell experiments are conducted to discuss the effects of composite hydrogels on cell growth and proliferation.The results show that GelMA-SBMA hydrogel in ratio of 5∶1,at a wavelength of 700 nm,presents a light transmittance of 94％.The good anti-protein adsorption ability is reflec-ted by the contact angle with fibrin above 90°.The vitro cell experiments show that SBMA is more conducive to cell growth and proliferation with good biocompatibility.
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维普
