Zn and B doped mechanically enhanced 45S5 bioactive glass scaffold
The 45S5 bioactive glass multi-hole scaffold is doped with B and Zn elements.The B element can ef-fectively reduce the melting temperature of the bioactive glass prepared by melting method,and reduce the damage of high temperature to the biological activity of 45S5 glass.It was observed by SEM that the micro-structure of the scaffold became denser after B doping,and the compressive test results show that the compres-sive strength of the B-doped glass scaffold was 2 to 3 times that of the pure 45S5 glass scaffold,up to 9.68 MPa.It shows that B also has a significant effect on the mechanical properties of the scaffold.However,the incorpo-ration of B elements can reduce the in vitro bioactivity of 45S5 glass scaffolds,and excessive B doping can also cause the scaffolds to be burned.After deter mining the relative optimal doping concentration of B element,the addition of Zn element to the glass scaffold can improve the sintering stability of the scaffold.The compressive strength of the scaffold can be continuously enhanced,and the optimal value can reach 14.52 MPa,which can match the properties of human cancellous bone.At the same time,the SEM images of the scaffolds immersed in SBF simulated body fluid for 7 days showed the incorporation of Zn element,which significantly improved the in vitro biological activity of 45S5 glass scaffolds.In summary,a mechanically enhanced bone repair material with good biological activity is prepared by co-doping B and Zn elements into 45S5 bioglass porous scaffolds,which has certain application value in bone tissue engineering.
45S5 bioactive glassbone tissue engineeringdoping with B and Zn elementsmechanical enhancement
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