Owing to the inappropriate use of antimicrobial agents and the process of natural selection of microor-ganisms,antibiotic resistance has become a serious problem that challenges the health of human beings.In-tegrating two different bactericidal agents into one matrix is a feasible approach to enhance antibacterial efficien-cy.This study synthesized an efficient antibacterial nanocomposite material by conjugating polydopamine-modi-fied silver nanoparticles(PDA@Ag)with amoxicillin(AMOX).The structure of PDA@Ag-AMOX(PAA)was characterized using TEM,UV-Vis,and FT-IR.Compared to PDA@Ag,PAA showed an increased inhibi-tion rate of 33.3％against Escherichia coli,31.3％against Bacillus subtilis,and 28.6％against Salmonella.It was speculated that the antimicrobial mechanism involved the reaction of Ag+derived from PAA with functional groups of vital enzymes and proteins and the inhibitory effect of AMOX on the synthesis of bacterial cell walls and carboxypeptidase activity of binding proteins.PAA has both good coordinated antibacterial activity and high biocompatibility,which lays the foundation for the future combination and the exploration of more collaborative treatment plans among antibacterial agents.
维普
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