Preparation of Sodium Alginate Freeze-Dried Gel Loaded with Grape Seed Polyphenols and Its Properties of Antimicrobial and Hemostatic
A freeze-dried gel containing sodium alginate loaded grape seed extract was prepared and its antibacterial and hemostatic properties were investigated.The freeze-dried gel SA/GSE/Fe3+(SGF(0.75))was obtained with the mixture of grape seed extract(GSE),sodium alginate(SA)and Fe3+ by being freeze-dried twice.Then the porosity,water absorption,photothermal properties,antibacterial properties,biocompatibility and hemostatic properties of SGF(0.75)freeze-dried gel were investigated through in vitro experiments.The prepared SGF(0.75)freeze-dried gel has a porosity of about 37%and a water absorption rate of about 1500%.Under near-infrared laser irradiation,SGF(0.75)freeze-dried gel can kill nearly 90%of Staphylococcus aureus and 91%of Escherichia coli.The hemostatic performance experiment shows that SGF(0.75)freeze-dried gel reduces blood loss and hemostatic time by 31%and 66%,respectively,in comparism with gauze.The prepared SGF(0.75)freeze-dried gel has strong hemostatic ability,good antibacterial effect,good biocompatibility,high safety,and can promote wound tissue healing.It has great application prospects in future clinical research.
sodium alginategrape seed extractphotothermal therapyantibacterialfreeze-dried gel
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