Preparation and Performance of Astragaloside-Loaded Core-Shell Nanofiber Wound Dressing
Coaxial astragaloside (AS)/polyvinylpyrrolidone (PVP)/polylactic acid (PLA) nanofiber functional dressings (AS/PVP/PLA) were prepared by coaxial electrostatic spinning technique. The micro-morphology,wettability,water vapor transmission rate and other properties of nanofiber dressings were characterized. The antioxidant capacity,antibacterial effect,and pro-diabetic chronic wound healing effect of the nanofiber dressings were also investigated. Results showed that the coaxial AS/PVP/PLA nanofiber functional dressing had an obvious core-shell structure and a smooth fiber surface,with a fiber diameter of (480±240) nm,a contact angle of (88.73±1.07)°,a water vapor transmission rate of (1660.42±80.61) g/(m2·d),and a free radical scavenging rate of 47％. AS/PVP/PLA nanofiber functional dressing significantly inhibited the growth of Escherichia coli and Staphylococcus aureus,and had a certain pro-healing effect on diabetic chronic wounds. The nanofiber dressings had good morphology and met the requirements,and had the potential to be developed as dressings for diabetic chronic wound healing.
万方数据
维普
